What Are Polynucleotides? 7 Things You Need To Know

New to polynucleotides? These seven simple points explain safety, results, and what to expect at your first visit.

1) What are polynucleotides, and are they safe?

Polynucleotides are chains of nucleotides – the natural building blocks of DNA and RNA. In aesthetics, they’re usually made from highly purified DNA sourced by fish using strict extraction and sterilisation.

Why DNA sourced by fish? It’s highly biocompatible with human tissue, so it’s well tolerated when prepared to medical standards. In short: you’re giving your skin clean, sterile building blocks that work with your body.

2) How do polynucleotides work?

Once injected, they help switch on your skin’s natural repair.

• Regeneration: They signal fibroblasts (the cells that make collagen and elastin) to work harder.
• Hydration and defence: They attract water for lasting moisture and act as antioxidants to help reduce everyday environmental stress.
• Calmer skin: Their anti-inflammatory action can soothe sensitive skin, supporting a clearer, more even look.

3) What results can I expect, and when?

You’ll see quick wins and steady gains:

• Hydration and texture: Smoother, plumper, fresher-looking skin within weeks.
• Fine lines and wrinkles: As collagen builds, lines soften and skin looks firmer and more lifted.
• Tone and pigmentation: A more even tone over time, helping reduce sun damage and patchiness.

Meanwhile, results will continue to build for several months as your skin renews from within.

4) Who is it for, and which areas can be treated?

Polynucleotides suit many skin types, including sensitive skin. They can also help with acne scarring, redness (including rosacea-prone skin), and signs of sun damage.

Common treatment areas:

• Face and neck: Overall rejuvenation, firmness, and fine lines
• Eye area: Crow’s feet, under-eye crepiness, and laxity
• Décolleté: Sun damage and texture
• Body: Texture on arms or abdomen, and the appearance of stretch marks

5) What happens during treatment?

Consultation: Your practitioner reviews your skin, goals, and suitability, then creates a tailored plan.

Treatment: A series of small injections with very fine needles. Most sessions take 30–45 minutes, depending on the areas treated.

Course: Typically three sessions, spaced two weeks apart, to build results gradually and comfortably.

6) Safety, side effects, and downtime

Polynucleotide treatments are known for minimal downtime. You may notice:

• Slight redness or small bumps at injection points
• Mild swelling or tenderness

These usually settle within hours. Therefore, most people resume their normal routine the same day. Any more questions? Contact us today.

7) How long do results last, and can I combine polynucleotides with other treatments?

You’ll see improvements within weeks, with benefits continuing for months as collagen and elastin rebuild. Results can last up to 12 months. Polynucleotides also pair well with other aesthetic treatments, enhancing overall outcomes and supporting skin health.

Evidence supports improvements in hydration, elasticity, firmness, and overall skin quality. For the best, most natural-looking results, choose experienced medical practitioners who understand how to customise your plan.

So, are you ready to explore polynucleotides? Let’s take a smart, science-led step towards smoother, healthier-looking skin and renewed confidence.